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High-Resolution Shortwave Infrared Imaging of Vascular Disorders Using Gold Nanoclusters

Abstract : We synthesized a generation of water-soluble, atomically precise gold nanoclusters (Au NCs) with anisotropic surface containing a short dithiol pegylated chain (AuMHA/TDT). The AuMHA/TDT exhibit a high brightness (QY ∼ 6%) in the shortwave infrared (SWIR) spectrum with a detection above 1250 nm. Furthermore, they show an extended half-life in blood (t 1/2ß = 19.54 ± 0.05 h) and a very weak accumulation in organs. We also developed a non-invasive, whole-body vascular imaging system in the SWIR window with high-resolution, benefiting from a series of Monte Carlo image processing. The imaging process enabled to improve contrast by 1 order of magnitude and enhance the spatial resolution by 59%. After systemic administration of these nanoprobes in mice, we can quantify vessel complexity in depth (>4 mm), allowing to detect very subtle vascular disorders non-invasively in bone morphogenetic protein 9 (Bmp9)-deficient mice. The combination of these anisotropic surface charged Au NCs plus an improved SWIR imaging device allows a precise mapping at high-resolution and an in depth understanding of the organization of the vascular network in live animals. KEYWORDS: shortwave infrared fluorescence, gold nanoclusters, vascular disorder, Monte Carlo restoration imaging processing, bone morphogenetic protein 9 (Bmp9)
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Zhixi Yu, Benjamin Musnier, Maxime Henry, K David Wegner, Benoit Chovelon, et al.. High-Resolution Shortwave Infrared Imaging of Vascular Disorders Using Gold Nanoclusters. ACS Nano, American Chemical Society, 2020, ⟨10.1021/acsnano.0c01174⟩. ⟨hal-02945280⟩



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