Chirurgie bariatrique, stomies et autres réductions du tube digestif : trop peu de données et de recommandations pour l’adaptation des thérapeutiques médicamenteuses

Abstract : Surgery modifying digestive tract may alter drugs pharmacokinetics. To maintain concentrations of active substance in their therapeutic ranges, a dosage adjustment or change of drug may be necessary. This is particularly important when no pharmacological or pharmacodynamic parameter reflecting the medication effectiveness is easily measurable. Our objective was to gather the information and documentary tools that can guide prescription in these patients with rearranged digestive tract. We searched information on the documentary portals of French agencies, on gray literature, on MEDLINE and in the summaries product characteristics. No information was found on the website of French agencies, sparse data were identified in gray literature. Some document are discordant, most are imprecise. One hundred and ten studies or case reports referenced on MEDLINE describe 79 medications pharmacokinetics after gastrointestinal surgery. Four are not available in France. Six literature reviews were found. Four summaries of product characteristics provided information related to drug absorption. No documentary tool adapted to clinical routine exists. This unsatisfactory situation is a barrier to optimal patients care. Information is available. It is however necessary to gather under an ergonomic shape adapted to clinical routine, bringing the surgery type, pharmacokinetic changes induced and what to do about the dose adjustment.
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Journal articles
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Contributor : Stephan Garcia <>
Submitted on : Tuesday, March 14, 2017 - 3:13:07 PM
Last modification on : Thursday, June 7, 2018 - 2:54:03 PM

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  • HAL Id : hal-01489677, version 1
  • DOI : 10.1016

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Elodie Bernard, Bruno Charpiat, Jean-Yves Mabrut, Xavier Dode, Stephan Garcia, et al.. Chirurgie bariatrique, stomies et autres réductions du tube digestif : trop peu de données et de recommandations pour l’adaptation des thérapeutiques médicamenteuses. La Presse Médicale, Elsevier Masson, 2015, 44 (11), pp.1162-68. ⟨10.1016⟩. ⟨hal-01489677⟩

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