Clomiphene citrate and neural tube defects: a meta‐analysis of controlled observational studies

Marine Auffret , Judith Cottin , Thierry Vial (1) , Michel Cucherat (2)

1 Service de Pharmacologie Toxicologie, Hospices Civils de Lyon, France
2 Evaluation et modélisation des effets thérapeutiques

At the end of the 80's several studies have suggested a potential increased risk of neural tube defects (NTDs) with ovulation induction/fertility drugs, especially with clomiphene citrate (CC). A previous meta-analysis of observational studies evaluating the risk of NTDs associated with the use of CC performed in 1995 found a risk ratio of 1.08 (95% confidence intervals (CI) 0.76-1.51). Since then, additional studies have been published and the risk of NTDs associated with periconceptional CC exposure may have changed.

Mots clés: neural tube defects; assisted reproductive technologies; birth defect; clomiphene citrate; meta-analysis

Domaines: Pharmacologie

Marine Auffret, Judith Cottin, Thierry Vial, Michel Cucherat. Clomiphene citrate and neural tube defects: a meta‐analysis of controlled observational studies. BJOG: An International Journal of Obstetrics and Gynaecology, 2019, ⟨10.1111/1471-0528.15800⟩. ⟨hal-02112945⟩