Clomiphene citrate and neural tube defects: a meta‐analysis of controlled observational studies

Abstract : At the end of the 80's several studies have suggested a potential increased risk of neural tube defects (NTDs) with ovulation induction/fertility drugs, especially with clomiphene citrate (CC). A previous meta-analysis of observational studies evaluating the risk of NTDs associated with the use of CC performed in 1995 found a risk ratio of 1.08 (95% confidence intervals (CI) 0.76-1.51). Since then, additional studies have been published and the risk of NTDs associated with periconceptional CC exposure may have changed.
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Submitted on : Saturday, April 27, 2019 - 1:05:30 PM
Last modification on : Monday, May 27, 2019 - 10:07:44 AM

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Marine Auffret, Judith Cottin, Thierry Vial, Michel Cucherat. Clomiphene citrate and neural tube defects: a meta‐analysis of controlled observational studies. BJOG: An International Journal of Obstetrics and Gynaecology, Wiley, 2019, ⟨10.1111/1471-0528.15800⟩. ⟨hal-02112945⟩

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