Clomiphene citrate and neural tube defects: a meta‐analysis of controlled observational studies - Archive ouverte HAL Access content directly
Journal Articles BJOG: An International Journal of Obstetrics and Gynaecology Year : 2019

Clomiphene citrate and neural tube defects: a meta‐analysis of controlled observational studies

, , (1) , (2)
1
2

Abstract

At the end of the 80's several studies have suggested a potential increased risk of neural tube defects (NTDs) with ovulation induction/fertility drugs, especially with clomiphene citrate (CC). A previous meta-analysis of observational studies evaluating the risk of NTDs associated with the use of CC performed in 1995 found a risk ratio of 1.08 (95% confidence intervals (CI) 0.76-1.51). Since then, additional studies have been published and the risk of NTDs associated with periconceptional CC exposure may have changed.
Not file

Dates and versions

hal-02112945 , version 1 (27-04-2019)

Identifiers

Cite

Marine Auffret, Judith Cottin, Thierry Vial, Michel Cucherat. Clomiphene citrate and neural tube defects: a meta‐analysis of controlled observational studies. BJOG: An International Journal of Obstetrics and Gynaecology, 2019, ⟨10.1111/1471-0528.15800⟩. ⟨hal-02112945⟩
56 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More