Antiretroviral-naive and -treated HIV-1 patients can harbour more resistant viruses in CSF than in plasma

Cathia Soulié 1 Diane Descamps 2 Vé Ronique Schneider Mary-Anne Trabaud Laurence Morand-Joubert 3 Constance Delaugerre 4 Brigitte Montes 5 Francis Barin 6 Virginie Ferré 7 Anne Maillard 8 Sophie Vallet 9 Catherine Roussel 10 Lambert Assoumou 1 Vincent Calvez 11 Philippe Flandre 1 Anne-Geneviè Ve H. Jeulin 12 A. Guigon E. Lagier H. Le Guillou C. Alloui D. Bettinger 13 C. Pallier 14 H. Fleury S. Reigadas 15 P. Bellecave 15 P. Recordon-Pinson C. Payan 16 A. Vabret 17 C. Henquell 18 A. Mirand 19 M. Bouvier-Alias 20 Alexis de Rougemont 21, 22, 23, 24 G. dos Santos P. Morand 25 A. Signori-Schmuck 26 L. Bocket S. Rogez 27 P. Andre 28 J. Tardy 29 C. Tamalet 30 C. Delamare E. Schvoerer 12 E. André-Garnier 31 J. Cottalorda 32 J. Guinard 33 A. Guiguon F. Brun-Vezinet C. Charpentier B. Visseaux G. Peytavin 34 A. Krivine 35 A. Si-Mohamed V. Avettand-Fenoel 36 A.-G. Marcelin 37 S. Lambert-Niclot 37 M. Wirden 37 M. Chaix C. Amiel 38 V. Schneider 39 G. Giraudeau V. Brodard J. Plantier C. Chaplain T. Bourlet 25 S. Fafi-Kremer 40 F. Stoll-Keller 41 M. Schmitt H. Barth 42 S. Yerly C. Poggi 43 J. Izopet 44 S. Raymond 45 A. Chaillon S. Marque-Juillet A. Roque-Afonso S. Haim-Boukobza Maxime Grude 37 D. Costagliola T. Allegre 46 J. Schmit J. Chennebault O. Bouchaud N. Magy-Bertrand 47 J. Delfraissy M. Dupon 48 P. Morlat D. Neau 49 S. Ansart 50 S. Jaffuel 51 R. Verdon 52 C. Jacomet Y. Levy S. Dominguez P. Chavanet 53 L. Piroth 54 A. Cabié 55 P. Leclercq F. Ajana A. Cheret P. Weinbreck L. Cotte 56 I. Poizot-Martin 57 I. Ravaud B. Christian F. Truchetet M. Grandidier J. Reynes 58 T. May 59 F. Goehringer 60 F. Raffi 61 P. Dellamonica 25 T. Prazuck 37 L. Hocqueloux P. Yeni R. Landman O. Launay 62 L. Weiss 63 J. Viard C. Katlama 64 A. Simon P. Girard 65 J. Meynard J. Molina 66 G. Pialoux B. Hoen 67 M. Goeger-Sow I. Lamaury G. Beaucaire R. Jaussaud 68 C. Rouger C. Michelet F. Borsa-Lebas F. Caron 69 M. Khuong F. Lucht 70 D. Rey 71 A. Calmy 72 B. Marchou G. Gras A. Greder-Belan D. Vittecoq 73 E. Teicher 74
11 MMCS - Modélisation mathématique, calcul scientifique
ICJ - Institut Camille Jordan [Villeurbanne]
42 Environment and Sustainable Development Programme
European Commission - DG Research and Innovation
45 MDN - Magnétisme et Diffusion Neutronique
MEM - Modélisation et Exploration des Matériaux : DRF/INAC/MEM
63 T2
LMOPS - Laboratoire Matériaux Optiques, Photonique et Systèmes
Abstract : Objectives: The neurological disorders in HIV-1-infected patients remain prevalent. The HIV-1 resistance in plasma and CSF was compared in patients with neurological disorders in a multicentre study. Methods: Blood and CSF samples were collected at time of neurological disorders for 244 patients. The viral loads were .50 copies/mL in both compartments and bulk genotypic tests were realized. Results: On 244 patients, 89 and 155 were antiretroviral (ARV) naive and ARV treated, respectively. In ARV-naive patients, detection of mutations in CSF and not in plasma were reported for the reverse transcriptase (RT) gene in 2/89 patients (2.2%) and for the protease gene in 1/89 patients (1.1%). In ARV-treated patients, 19/152 (12.5%) patients had HIV-1 mutations only in the CSF for the RT gene and 30/151 (19.8%) for the protease gene. Two mutations appeared statistically more prevalent in the CSF than in plasma: M41L (P ¼ 0.0455) and T215Y (P ¼0.0455). Conclusions: In most cases, resistance mutations were present and similar in both studied compartments. However, in 3.4% of ARV-naive and 8.8% of ARV-treated patients, the virus was more resistant in CSF than in plasma. These results support the need for genotypic resistance testing when lumbar puncture is performed.
Keywords : CSF ARV HIV resistance
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Cathia Soulié, Diane Descamps, Vé Ronique Schneider, Mary-Anne Trabaud, Laurence Morand-Joubert, et al.. Antiretroviral-naive and -treated HIV-1 patients can harbour more resistant viruses in CSF than in plasma. Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2015, 70 (2), pp.566-572. ⟨10.1093/jac/dku419⟩. ⟨hal-02291062⟩

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